Ophthalmologica highlights

Volume: 241 Issue: 3 Month: March 2019

Sebastian Wolf

Posted: Wednesday, May 1, 2019

Higher incidence of RVO in glaucomatous eyes
In a retrospective cohort study, a multivariate analysis of the records of 300 pseudoexfoliative (PXF) glaucoma patients and 300 non-PXF glaucoma patients yielded a significantly higher probability for retinal vein occlusion (RVO) when compared with 599 non-glaucoma non-PXF patients, with odds ratios of 2.29 and 3.03, respectively, and a p value of 0.005. The odds ratio for central RVO was especially elevated in the PXF and non-PXF glaucomatous groups, at 3.64 and 3.78, respectively (p=0.013). However, there was no significant difference between the PXF and non-PXF glaucoma groups regarding RVO (p=0.541), CRVO (p=0.092) or branch RVO (p=0.774).
G Antman et al, “The Incidence of Retinal Vein Occlusion in Patients with Pseudoexfoliation Glaucoma: A Retrospective Cohort Study”, Ophthalmologica 2019, volume 241, Issue 3.

Duration not amount of anti-VEGF treatment a primary risk factor for RPE atrophy
The post-hoc analysis of 52 neovascular age-related macular degeneration (AMD) patients without baseline retinal pigment epithelium (RPE) atrophy, who were treated with nine or more anti-vascular endothelial growth factor (VEGF) injections for three or more years, showed that the onset of concomitant RPE atrophy was significantly associated with the duration of nAMD treatment (mean 5.34 years; odds ratio = 1.83, p=0.012) but not the number of injections of anti-VEGF, delay to the first treatment or baseline intraocular VEGF.
V Sitnilska et al, “Onset of Retinal Pigment Epithelium Atrophy Subsequent to Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration”, Ophthalmologica 2019, volume 241, Issue 3.

Gender differences found in chorioretinal microvasculature of children
Both diabetic and non-diabetic male and female children have significant differences in their foveal avascular zone (FAZ) and retinal thickness, according to a new study. Optical coherence angiography (OCT-A) and structural OCT examination in 233 diabetic children and 62 healthy children showed that the deep capillary plexus FAZ area in boys was significantly smaller than in girls both in diabetics (p=0.0010) and healthy children (p=0.0302). The superficial capillary plexus FAZ area was significantly smaller in boys with diabetes compared to girls with the condition (p=0.0006), and compared to controls (p=0.0870). Central retinal thickness was significantly greater in diabetic boys than in diabetic girls (p=0.0001) and controls (p=0.1008).
Niestrata-Ortiz M, “Sex-Related Variations of Retinal and Choroidal Thickness and Foveal Avascular Zone in Healthy and Diabetic Children Assessed by Optical Coherence Tomography Imaging”, Ophthalmologica 2019, volume 241, Issue 3.