Ophthalmologica – Edited by Sebastian Wolf

Vol: 243 Issue: 1

Sebastian Wolf

Posted: Saturday, February 1, 2020

OCT-A reliable and reproducible
Optical coherence tomography angiography (OCT-A) measurements of the retinal Macular Microvasculature with Spectralis II OCT are reliable and repeatable according to new study. In the prospective trial, 23 eyes of 23 persons underwent en face OCT-A imaging in combination with a newly made software, the Erlangen-Angio-Tool (EA-Tool). Bland-Altman plots showed a good reliability of two consecutive scans of each sector and testing of reproducibility showed no statistically significantly different sectorial coefficients of variation. S Hosari et al, “OCT Angiography: Measurement of Retinal Macular Microvasculature with Spectralis II OCT Angiography – Reliability and Reproducibility”, Ophthalmologica 2020, volume 243, issue 1.

Visual decline in AMD patients receiving anti-VEGF frequently a result of undertreatment

A review of studies of anti-Vascular Endothelial Growth Factor (Anti-VEGF) agents in neovascular AMD patients and their extension studies published from January 1, 2013, to June 30, 2018, shows that clinical trials demonstrated that initial visual acuity (VA) gains maintained for up to seven years. However, in real-world practice studies, patients are usually undertreated, with a corresponding decline in VA over time. 
A primary reason is the general mindset in the ophthalmological community that sustained benefits with treatment are not possible, the authors maintain. J Mones et al, “Undertreatment of Neovascular Age-Related Macular Degeneration after 10 Years of Anti-Vascular Endothelial Growth Factor Therapy in the Real World: The Need for A Change of Mindset”, Ophthalmologica 2020, volume 243, issue 1.

Complementary use of FA and OCT-A ensures the best approach in diabetic retinopathy patients

Fluorescein angiography and OCT-A have their individual strengths and are best used in combination in patients with diabetic retinopathy, a new study suggests. In 42 diabetic retinopathy patients who underwent fluorescein angiography (FA) and en face OCT-A, the mean size of the foveal avascular zone (FAZ) was 0.39 mm2 when measured with FA and 0.42 mm2 when measured by OCTA and the mean microaneurysm count was 14 when measured by FA and 13 when measured by OCT-A. The assessability was favourable to OCT-A in 38-41/53 eyes regarding the FAZ and favourable to FA in 45-49/53 eyes regarding MAs. C Enders, et al, “Comparison between Findings in Optical Coherence Tomography Angiography and in Fluorescein Angiography in Patients with Diabetic Retinopathy”, Ophthalmologica 2020, volume 243, issue 1.

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